Catalog

2’-Fluoro RNA oligonucleotides contain fluorine atom at 2'-position of sugar moiety instead of native 2'-hydroxy group that slightly increases binding affinity (melting temperature, Tm) to RNA and nuclease resistance. Unique features of 2’-fluoro nucleotides – preferred 2’-exo-3’-endo conformation of the sugar ring and the size of fluorine atom being close to hydroxy group, makes this modification the closest mimic of natural ribonucleotides. 2’-Fluoro oligonucleotides are beneficial for many applications including Antisense oligonucleotides, ribozymes, aptamers and siRNA.

Available sites for modifications are 5’, internal, and 3’.