- Life Science
- In vitro diagnostics
- Synthesis of oligonucleotides
- Primers
- Fluorescently labeled probes and samples
- Oligonucleotides GentaOligoPure
- Modifications
- ‘Click’ chemistry modifications
- 2'-F (2'-Fluoro) RNA modification
- Phosphorothioate bonds
- 2'-MOE (2'-O-Methoxyethyl) RNA modification
- 2'-OMe (2'-O-Methyl) RNA modification
- LNA (Locked Nucleic Acid) RNA modification
- Other modifications
- Phosphorylation
- Thiophosphate bonds
- Fluorophores and quenchers
- Linkers and functionalization
- Reagents for molecular biology
- Services
Thiophosphate bonds
One of the oxygen atoms in the phosphate residue of the oligonucleotide can be replaced by a sulfur atom to form a thiophosphate bond, the presence of which increases the resistance of oligonucleotides to degradation by nucleases, and also improves the pharmacokinetics and pharmacodynamics in vivo.
Note! Thiophosphates can lead to an increase in the toxicity of oligonucleotides, we recommend that toxicity be assessed before use in vitro and in vivo.
Available position for modification is internal.
Conventions: *
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