Catalog

Non-bridging oxygen in phosphates can be substituted by a sulfur atom in oligonucleotides. Phosphorothioates increase oligonucleotide resistance to degradation by nucleases and improve PK/PD in vivo.

Note! Sometimes phosphorothioates might increase oligonucleotide toxicity, so accurate tox evaluation is always needed for in vitro and in vivo applications.

Available site for modification is internal.