Catalog

Terminal alkyne is a functional group, which can be incorporated into oligonucleotide internally or at 5’- and 3’-ends. Alkyne oligonucleotides can be conjugated with azide-containing labels/tags (e.g., fluorescent dyes, biotin, or oligos) with high regioselectivity and efficiency using “Click Chemistry” (a [3+2] cycloaddition in presence of copper (I) ions).

Available sites for modifications are 5’, internal, and 3’.

Note: The internal modification can be introduced via dT or via Prolinol.