- Life Science
- In vitro diagnostics
- Synthesis of oligonucleotides
- Primers
- Fluorescently labeled probes and samples
- Oligonucleotides GentaOligoPure
- Modifications
- ‘Click’ chemistry modifications
- 2'-F (2'-Fluoro) RNA modification
- Phosphorothioate bonds
- 2'-MOE (2'-O-Methoxyethyl) RNA modification
- 2'-OMe (2'-O-Methyl) RNA modification
- LNA (Locked Nucleic Acid) RNA modification
- Other modifications
- Phosphorylation
- Thiophosphate bonds
- Fluorophores and quenchers
- Linkers and functionalization
- Reagents for molecular biology
- Services
2'-OMe (2'-O-Methyl) RNA modification
2’-OMe modification in oligonucleotides provide several features like rapid hybridization kinetics to complementary RNA, thermal stability of duplexes, and resistance to nucleases. This modification is beneficial for Antisense oligonucleotides and siRNA. However, duplexes of fully 2′-OMe-modified oligonucleotides with RNA does not support RNase H activity, so gapmer approach is needed to resolve this issue.
Available sites for modifications are 5’, internal, and 3’.
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