- Life Science
- In vitro diagnostics
- Synthesis of oligonucleotides
- Primers
- Fluorescently labeled probes and samples
- Oligonucleotides GentaOligoPure
- Modifications
- ‘Click’ chemistry modifications
- 2'-F (2'-Fluoro) RNA modification
- Phosphorothioate bonds
- 2'-MOE (2'-O-Methoxyethyl) RNA modification
- 2'-OMe (2'-O-Methyl) RNA modification
- LNA (Locked Nucleic Acid) RNA modification
- Other modifications
- Phosphorylation
- Thiophosphate bonds
- Fluorophores and quenchers
- Linkers and functionalization
- Reagents for molecular biology
- Services
2'-MOE (2'-O-Methoxyethyl) RNA modification
2’-MOE oligonucleotides demonstrate enhanced binding affinity to the target RNAs, serum proteins and an excellent resistance to ubiquitous nucleases in vitro and in vivo [DOI: 10.1016/j.jbc.2021.100416]. 2’-MOE RNA modification is introduced in 5’-/3’- wings of gapmer ASO to increase RNA binding affinity and resistance to nucleases. Duplexes of fully 2'-MOE-modified oligonucleotides with RNA does not support RNase H activity, which makes them useful as splice-switching oligonucleotides.
Available sites for modifications are 5’, internal, and 3’.
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