- Life Science
- In vitro diagnostics
- Synthesis of oligonucleotides
- Primers
- Fluorescently labeled probes and samples
- Oligonucleotides GentaOligoPure
- Modifications
- ‘Click’ chemistry modifications
- 2'-F (2'-Fluoro) RNA modification
- Phosphorothioate bonds
- 2'-MOE (2'-O-Methoxyethyl) RNA modification
- 2'-OMe (2'-O-Methyl) RNA modification
- LNA (Locked Nucleic Acid) RNA modification
- Other modifications
- Phosphorylation
- Thiophosphate bonds
- Fluorophores and quenchers
- Linkers and functionalization
- Reagents for molecular biology
- Services
1,2-dideoxyribose
1,2-dideoxyribose mimics abasic sites in DNA, so this modification can be useful for study DNA damage and repair. Hence, most of applications rely on dSpacer as a rigid spacer in DNA oligonucleotides. dSpacer fixes a more rigid structure of oligonucleotides in comparison to oligoethylene linkers, but DNA polymerases cannot bypass 1,2-dideoxyribose. Multiple incorporation of dSpacer can be useful in STR analysis and genotyping. Inverted (3’→5’) 1,2-dideoxyribose is a recognize protector of oligonucleotides from nucleases and can be used in ASO and siRNA for in vivo applications.
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